DETAILED NOTES ON CONOLIDINE

The first asymmetric total synthesis of conolidine was made by Micalizio and coworkers in 2011.[2] This artificial route enables use of both enantiomer (mirror image) of conolidine via an early enzymatic resolution."We verified that conolidine binds into the recently recognized opioid receptor ACKR3, whilst showing no affinity for another 4 classic